2000年以降の代表的論文

全リスト約400報は下記URLを参照。

https://www.ncbi.nlm.nih.gov/myncbi/takaomi.saido.1/bibliography/public/

  1. Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., Kawashima-Morishima, M., Lee, H.-.J., Hama, E., Sekine-Aizawa, Y., Saido, T.C. (2000). Identification of the major Ab1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nature Med., 6, 143-151. (Times cited as of May 1, 2023: 701)
  2. Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N.P., Gerard, C., Hama, E., Lee, H.-J., Saido, T.C. (2001). Metabolic regulation of brain Ab by neprilysin. Science, 292, 1550-1552. (Times cited: 789)
  3. Saito, T., Takaki, Y., Iwata, N., Trojanowski, J., Saido T.C. (2003). Perspectives: Alzheimer’s disease, neuropeptides, neuropeptidase, and amyloid-b peptide metabolism. Science (SAGE-KE), http:// sageke.sciencemag.org/cgi/content/full/sageke; 2003/3/pe1.  [2003(3): PE1].
  4. Tsubuki, S., Takaki, Y., Saido, T.C. (2003). Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Ab to physiologically relevant proteolytic degradation. Lancet, 361, 1957-1958. (Times cited: 116)
  5. Iwata, N., Mizukami, H., Shirotani, K., Takaki, Y., Muramatsu, S., Gerard, N., Gerard, C., Ozawa, K., Saido, T.C. (2004). Presynaptic localization of neprilysin contributes to efficient clearance of amyloid b peptide in mouse brain. J. Neurosci., 24, 991-998.
  6. Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.-H., Suemoto, T., Higuchi, M., Saido, T.C. (2005). Somatostatin regulates brain amyloid b peptide, Ab42, through modulation of proteolytic degradation. Nature Med., 11, 434-439. (Times cited: 282)
  7. Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., Saido T.C. (2005). 19F- and 1H-MRI detection of amyloid-b peptide in vivo. Nature Neurosci., 8, 527-533. (Times cited: 291)
  8. Saito, T., Suemoto, T., Brouwers, N., Sleegers, K., Funamoto, S., Mihira, M., Matsuba, Y., Yamada, K., Nilsson, P., Takano, J., Nishimura, M., Iwata, N., Van Broeckhoven, C., Ihara, Y., Saido, T.C. (2011) Potent amyloidogenicity and pathogenicity of Ab43. Nature Neurosci.,14, 1023-1032. (Times cited: 203)
  9. Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., Saido, T.C. (2013) Aβ secretion and plaque formation depend on autophagy. Cell Reports, 5(19), 61-69, doi: 10.1016/j.celrep.2013.08.042. (Times cited: 320)
  10. Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., Saido, T.C. (2014) Single App knock-in mouse models of Alzheimer’s disease. Nat. Neurosci., 17, 661-663. (Times cited: 530)
  11. Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. (2013) Ab secretion and plaque formation depend on autophagy. Cell Reports, 5(19), 61-69, doi: 10.1016/j.celrep.2013.08.042. (Times cited: 320)
  12. Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. (2017) APP mouse models for Alzheimer’s disease preclinical studies. EMBO J, 36, 2473-2487. (Times cited: 362)
  13. Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. (2018) Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun, 9(1):2282.  doi: 10.1038/s41467-018-05262-w. (Times cited: 37)
  14. Nagata K, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC. (2018) Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology. Nat Commun, 9(1) :1800. doi: 10.1038/s41467-018-04238-0. (Times cited: 19)
  15. Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Murayama S, Saido TC, Saito T. (2019) Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nat Commun, 10(1):2394 doi: 10.1038/s41467-019-10278-x. (Times cited:32)
  16. Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. (2019) Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation. J Biol Chem, 294(34), 12754-12765. (Times cited: 63)
  17. Watamura N, Kakiya N, Nilsson P, Tsubuki S, Kamano N, Takahashi M, Hashimoto S, Sasaguri H, Saito T, Saido TC. (2022) Somatostatin-evoked Ab catabolism in the brain: Mechanistic involvement of a-endosulfine-K ATP channel pathway. Mol Psychiatry, 27, 1816–1828 doi: 10.1038/s41380-021-01368-8. (Times cited: 2)
  18. Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nillson P, Winblad B, Saito T, Iwata N, Saido TC. (2022) Recent Advances in the Modeling of Alzheimer’s Disease. Front Neurosci, 16:807473, doi: 10.3389/fnins.2022.807473. (Times cited: 10)